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Successful delivery after the transfer of embryos obtained from a cohort of incompletely in vivo matured oocytes at retrieval time.

Fauque P, Guibert J, Jouannet P, Patrat C

Laboratoire de Biologie de la Reproduction, Hôpital Cochin, AP-HP, Université René-Descartes, Paris, France. patricia.fauque@cch.aphp.fr

OBJECTIVE: To report a case of successful delivery of a healthy baby after intracytoplasmic sperm injection (ICSI) in a patient with no mature oocytes at the time of oocyte retrieval. DESIGN: Case report. SETTING: Department of Reproductive Medicine. PATIENT: After a controlled ovarian hyperstimulation cycle, a total of seven immature oocytes were collected. INTERVENTION(S): Medical management. MAIN OUTCOME MEASURE(S): The timing of polar body extrusion was checked every 2 hours, and ICSI was performed as soon as the first polar body was extruded. RESULT(S): Following incubation in culture medium, five oocytes reached the metaphase II stage within 8-8.5 hours. Three oocytes were fertilized after ICSI, and two of three cleaved embryos were transferred on day 3. The embryo transfer was followed by a single pregnancy and the delivery of a healthy baby. CONCLUSION: This case report demonstrates that embryos obtained from in vitro matured oocytes retain the developmental competence for full-term. It illustrates the importance of regularly monitoring the polar body extrusion when all collected oocytes are immature.

Published 14 April 2008 in Fertil Steril, 89(4): 991.e1-4.
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