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Birth of a healthy boy after fertilization of cryopreserved oocytes with cryopreserved testicular spermatozoa from a man with nonmosaic Klinefelter syndrome.

Greco E, Iacobelli M, Rienzi L, Fabris GF, Tesorio N, Tesarik J

Center for Reproductive Medicine, European Hospital, Rome, Italy.

OBJECTIVE: To report the first birth with frozen spermatozoa and frozen oocytes in a case of nonmosaic Klinefelter syndrome. DESIGN: Case report. SETTING: Private IVF clinics and a university hospital. PATIENT(S): A 32-year-old woman and a 33-year-old man. INTERVENTION(S): Testicular sperm extraction and cryopreservation, oocyte recovery and cryopreservation, intracytoplasmic sperm injection. MAIN OUTCOME MEASURE(S): Assessment of fertilization and chromosomal analysis of newborn child. RESULT(S): Three oocytes were injected and one embryo was obtained, resulting in the birth of a normal (46,XY) boy. CONCLUSION(S): Cryopreserved spermatozoa from a patient with nonmosaic Klinefelter syndrome can form normal embryos even with cryopreserved oocytes.

Published 14 April 2008 in Fertil Steril, 89(4): 991.e5-7.
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