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Dynamics of pituitary down-regulation and ovarian response to controlled stimulation in in vitro fertilization cycles.

Mohamed KA, Davies WA, Lashen H

Centres for Assisted Reproduction (CARE Fertility), Cliftonville, Northampton, United Kingdom. kamel.mohamed@ntlworld.com <kamel.mohamed@ntlworld.com>

The effect of the daily GnRH agonist administration on LH levels and ovarian response after down-regulation was investigated in 2 groups of women who received recombinant FSH versus hMG. The results showed that the pituitary gland remained responsive to the daily buserelin by producing pulses of LH, despite down-regulation in both groups; however, the patients whose condition is profoundly down-regulated may need exogenous LH to improve their response.

Published 5 February 2007 in Fertil Steril, 87(2): 433-5.
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