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Postnatal respiratory distress in a dichorial twin with congenital thoracic neuroblastoma after assisted reproduction by intracytoplasmatic sperm injection.

Langer T, Deeg KH, Hümmer P, Paulides M, Beck JD, Klinge J

University Clinic for Children and Adolescents, Erlangen, Germany. thorsten.langer@kinder.imed.uni-erlangen.de

We report on the case of a female twin with congenital thoracic neuroblastoma after conception via intracytoplasmatic sperm injection (ICSI). Birth occurred at 37 + 1-week gestation per primary sectio caesarea. Acute respiratory distress necessitated intubation and mechanical ventilation. Ultrasound and magnetic resonance imaging (MRI) showed a mass in the right upper thorax compressing the trachea. The tumor was subtotally excised and histological analysis revealed neuroblastoma. No further treatment was given. The residual primary tumor regressed spontaneously. Four years after diagnosis, both twins are healthy and normally developed.

Published 10 January 2007 in Pediatr Blood Cancer, 48(3): 358-60.
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