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Elevated serum müllerian-inhibiting substance may be a marker for ovarian hyperstimulation syndrome in normal women undergoing in vitro fertilization.

Nakhuda GS, Chu MC, Wang JG, Sauer MV, Lobo RA

Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, USA. gsn16@columbia.edu

We identified patients who experienced ovarian hyperstimulation syndrome (OHSS) (n = 16) and compared their baseline pretreatment levels of müllerian-inhibiting substance (MIS) to age- and weight-matched patients with normal responses to gonadotropins (n = 14). Baseline serum MIS in patients with OHSS were sixfold higher than those seen in normal controls (3.62 +/- 0.87 vs. 0.63 +/- 0.09 ng/mL; P=.0036), indicating that MIS could potentially serve as a useful marker for identifying patients at risk for OHSS.

Published 1 May 2006 in Fertil Steril, 85(5): 1541-3.
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